Ventricular Hypertrophy
نویسندگان
چکیده
Background. Chronic cocaine abuse has been associated with a high prevalence of left ventricular hypertrophy (LVH) in normotensive individuals at rest. This study was conducted to determine whether chronic cocaine abusers with LVH would manifest an exaggerated pressor response to treadmill exercise. Methods and Results. Forty-nine normotensive chronic cocaine abusers underwent Bruce protocol treadmill exercise testing until they attained 85% maximum predicted heart rate. A peak exercise systolic blood pressure .210 mm Hg was defined as abnormal. In addition, they underwent two-dimensional echocardiography and had left ventricular mass determined by the area-length method. LVH was defined as left ventricular mass .105 g/m2 and a posterior wall thickness >1.2 cm. Ageand race-matched control subjects also underwent echocardiography and exercise testing. Group differences in peak exercise blood
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